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Targeted Allele Detail
Symbol: Car3tm1Gkim
Name: carbonic anhydrase 3; targeted mutation 1, Geumsoo Kim
MGI ID: MGI:3511866
Gene: Car3  Location: Chr3:14863512-14872523 bp, + strand  Genetic Position: Chr3, 3.22 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:94222
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe targeting event replaced 4.2 kb of DNA containing exons 3, 4 and 5 with a neomycin resistance (PGK-neo ) cassette. Northern and western blot analyses verified that mRNA and protein encoded by the targeted gene are both absent in tissues of homozygous mutant mice. Microarray analysis revealed a small (~30% +/- 10%) but statistically significant increase in Car13 transcript levels in mice lacking CAR3. (J:94222)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Car3 Mutation:  5 strains or lines available
Original:  J:94222 Kim G, et al., Carbonic anhydrase III is not required in the mouse for normal growth, development, and life span. Mol Cell Biol. 2004 Nov;24(22):9942-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory