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Traf2tm1.1Rbr
Targeted Allele Detail
Nomenclature
Symbol: Traf2tm1.1Rbr
Name: TNF receptor-associated factor 2; targeted mutation 1.1, Robert Brink
MGI ID: MGI:3511496
Synonyms: Traf2delta
Gene: Traf2  Location: Chr2:25517982-25546940 bp, - strand  Genetic Position: Chr2, 17.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93890
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele was generated by removing the floxed exon 3 from Traf2tm1Rbr via transient expression of Cre recombinase in recombinant ES cells. Excision of exon 3 resulted in a reading frame shift and introduced a premature stop codon. (J:93890)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Traf2 Mutation:  16 strains or lines available
References
Original:  J:93890 Grech AP, et al., TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. Immunity. 2004 Nov;21(5):629-42
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory