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Traf2tm1Rbr
Targeted Allele Detail
Nomenclature
Symbol: Traf2tm1Rbr
Name: TNF receptor-associated factor 2; targeted mutation 1, Robert Brink
MGI ID: MGI:3511494
Synonyms: Traf2lox
Gene: Traf2  Location: Chr2:25517982-25546940 bp, - strand  Genetic Position: Chr2, 17.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93890
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 3 was flanked by loxP sites followed by a floxed neo cassette. The neo cassette was removed in ES cells by transient transfection with a vector driving expression of Cre recombinase, leaving exon 3 flanked by loxP sites. Western blot analysis of lymph node B cells showed that expression levels did not differ from that of wild-type. (J:93890)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Traf2 Mutation:  9 strains or lines available
References
Original:  J:93890 Grech AP, et al., TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. Immunity. 2004 Nov;21(5):629-42
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory