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Ppargtm2(tTA)Yba
Targeted Allele Detail
Nomenclature
Symbol: Ppargtm2(tTA)Yba
Name: peroxisome proliferator activated receptor gamma; targeted mutation 2, Yaacob Barak
MGI ID: MGI:3511358
Synonyms: Ppargldi, Ppargtm2Yba
Gene: Pparg  Location: Chr6:115360951-115490399 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Lipodystrophy phenotypes of Ppargtm2(tTA)Yba/Pparg+ mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125992
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Transactivator)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with an Idi cassette that contains an IRES-tTA, neo, poly-adenylation signal, TetO and flag-tagged cDNA. While expression is modest in adipose tissue, it is poor in the liver and placenta. (J:125992)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:  28 strains or lines available
References
Original:  J:125992 Kim S, et al., A mouse model of conditional lipodystrophy. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16627-32
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/16/2018
MGI 6.12
The Jackson Laboratory