About   Help   FAQ
Ppargc1atm1Brsp
Targeted Allele Detail
Nomenclature
Symbol: Ppargc1atm1Brsp
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; targeted mutation 1, Bruce M Spiegelman
MGI ID: MGI:3511352
Synonyms: PGC-1alpha-
Gene: Ppargc1a  Location: Chr5:51611592-51725068 bp, - strand  Genetic Position: Chr5, 27.02 cM, cytoband C1
Ppargc1atm1Brsp/Ppargc1atm1Brsp mice develop dilated cardiomyopathy in response to transverse aortic constriciton (TAC)

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93896
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele resulted from the crossing of Ppargc1atm2Brsp with mice expressing cre recombinase in the germline. Exons 3-5 were removed from the locus. Northern and Western blot analyses indicated a lack of transcript and protein in mutants. (J:93896)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ppargc1a Mutation:  29 strains or lines available
References
Original:  J:93896 Lin J, et al., Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 2004 Oct 1;119(1):121-35
All:  84 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/23/2021
MGI 6.17
The Jackson Laboratory