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Syngap1tm1.1Mabk
Targeted Allele Detail
Nomenclature
Symbol: Syngap1tm1.1Mabk
Name: synaptic Ras GTPase activating protein 1 homolog (rat); targeted mutation 1.1, Mary B Kennedy
MGI ID: MGI:3511175
Synonyms: SG-, synGAP-, Syngap1tm1Mabk
Gene: Syngap1  Location: Chr17:26941253-26972434 bp, + strand  Genetic Position: Chr17, 13.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93969
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA neo cassette flanked by loxP sites inserted into intron 3 and an additional loxP site within exon 9 via homologous recombination. Expression of Cre recombinase in recombinant ES cells resulted in the deletion of exons 4-9. Western blot analysis confirmed the absence of protein in hippocampal homogenates at P0 and in hippocampal neurons cultured for 10 days. (J:93969)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Syngap1 Mutation:  23 strains or lines available
References
Original:  J:93969 Vazquez LE, et al., SynGAP regulates spine formation. J Neurosci. 2004 Oct 6;24(40):8862-72
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory