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Targeted Allele Detail
Symbol: Zic1/Zic4tm1Kjmi
Name: zinc finger protein of the cerebellum 4; targeted mutation 1, Kathleen J Millen
MGI ID: MGI:3510681
Synonyms: Zic1-Zic4-
Gene: Zic4  Location: Chr9:91362413-91389348 bp, + strand  Genetic Position: Chr9, 48.26 cM
Germline Transmission:  Earliest citation of germline transmission: J:93955
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intergenic deletion
Mutation detailsA targeting vector was designed to replace the 17.6 kb region between Zic1 and Zic4, as well as the coding region of the first exon of Zic4 and the entire first exon of Zic1. Transient Cre expression removed the neo in ES cells. (J:93955)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zic4 Mutation:  3 strains or lines available
Original:  J:93955 Grinberg I, et al., Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation. Nat Genet. 2004 Oct;36(10):1053-5
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory