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Targeted Allele Detail
Symbol: Zic4tm2Kjmi
Name: zinc finger protein of the cerebellum 4; targeted mutation 2, Kathleen J Millen
MGI ID: MGI:3510678
Synonyms: Zic4-
Gene: Zic4  Location: Chr9:91247636-91271404 bp, + strand  Genetic Position: Chr9, 48.26 cM
Germline Transmission:  Earliest citation of germline transmission: J:93955
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace the coding region of the first exon with a loxp flanked neo. Transient Cre expression removed the neo in ES cells. (J:93955)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zic4 Mutation:  18 strains or lines available
Original:  J:93955 Grinberg I, et al., Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation. Nat Genet. 2004 Oct;36(10):1053-5
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory