Zic4^tm2Kjmi
Targeted Allele Detail

Summary

• Symbol: Zic4^tm2Kjmi
• Name: zinc finger protein of the cerebellum 4; targeted mutation 2, Kathleen J Millen
• MGI ID: MGI:3510678
• Synonyms: Zic4^-
• Gene: Zic4 Location: Chr9:91247636-91271404 bp, + strand Genetic Position: Chr9, 48.26 cM
• Alliance: Zic4^tm2Kjmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93955
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the coding region of the first exon with a loxp flanked neo. Transient Cre expression removed the neo in ES cells. (J:93955)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zic4 Mutation: 24 strains or lines available

References

• Original: J:93955 Grinberg I, et al., Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation. Nat Genet. 2004 Oct;36(10):1053-5
• All: 3 reference(s)