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Cpb2tm1Nok
Targeted Allele Detail
Nomenclature
Symbol: Cpb2tm1Nok
Name: carboxypeptidase B2 (plasma); targeted mutation 1, Noriko Okada
MGI ID: MGI:3510646
Synonyms: proCPR-
Gene: Cpb2  Location: Chr14:75242287-75283551 bp, + strand  Genetic Position: Chr14, 39.73 cM, cytoband D2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93733
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 and 5, encoding some of the zinc and substrate binding sites, were replaced with a neomycin resistance gene. RT-PCR of mutant liver samples confirmed successful recombination, with bands shorter than wild-type by 200 bp, the length of exons 4 and 5. proCPR- (J:93733)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cpb2 Mutation:  9 strains or lines available
References
Original:  J:93733 Asai S, et al., Absence of procarboxypeptidase R induces complement-mediated lethal inflammation in lipopolysaccharide-primed mice. J Immunol. 2004 Oct 1;173(7):4669-74
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory