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Spontaneous Allele Detail
Symbol: Gulosfx-2J
Name: gulonolactone (L-) oxidase; spontaneous fracture 2 Jackson
MGI ID: MGI:3510598
Gene: Gulo  Location: Chr14:66224235-66246656 bp, - strand  Genetic Position: Chr14, 34.36 cM
Fracture site with extensive callus formation in Gulosfx-2J/Gulosfx-2J mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  RB156Bnr/Ei-Dsprul/GrsrJ
Allele Type:    Spontaneous
Mutation:    Undefined
Mutation detailsThis spontaneous mutation arose at The Jackson Laboratory in 2002. A noncomplementation test with Gulosfx demonstrated that this is an additional allele of Gulo.
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gulo Mutation:  18 strains or lines available

The ruffled mutation in the background strain is still segregating in the RB156BNR/Ei-rul/J- Gulosfx-2J strain and when homozygous causes the Gulosfx-2J mice to have a ruffled looking coat.

The phenotype of this remutation is more severe than the original sfx mutation, suggesting a modifying gene may be present in the RB156BNR/Ei-rul/J background strain.

Original:  J:96441 Harris BS, et al., Spontaneous fracture 2 Jackson (sfx2J), a second mutation of the gulonolactone oxidase gene (Gulo). MGI Direct Data Submission. 2005;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory