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Targeted Allele Detail
Symbol: Mmp19tm1Amp
Name: matrix metallopeptidase 19; targeted mutation 1, Alberto M Pendas
MGI ID: MGI:3505589
Synonyms: Mmp19-
Gene: Mmp19  Location: Chr10:128790910-128800824 bp, + strand  Genetic Position: Chr10, 77.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:90802
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo cassette replaced a 3 kb fragment containing 1 kb of the promoter and exons 1 and 2 via homologous recombination. Northern blot analysis confirmed absence of RNA in liver, lung and ovary. (J:90802)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp19 Mutation:  11 strains or lines available
Original:  J:90802 Pendas AM, et al., Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice. Mol Cell Biol. 2004 Jun;24(12):5304-13
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory