Ppia^tm1Lubn
Targeted Allele Detail

Summary

• Symbol: Ppia^tm1Lubn
• Name: peptidylprolyl isomerase A; targeted mutation 1, Jeremy Luban
• MGI ID: MGI:3505553
• Synonyms: CypA^-, Ppia^-
• Gene: Ppia Location: Chr11:6365867-6369817 bp, + strand Genetic Position: Chr11, 3.97 cM
• Alliance: Ppia^tm1Lubn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93591
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced all but the last 60 bp of the coding sequence. Immunoblot analysis confirmed absence of protein in thymus, spleen, kidney, and brain. (J:64523)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ppia^tm1Lubn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppia Mutation: 18 strains or lines available

References

• Original: J:93591 Colgan J, et al., Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk. Immunity. 2004 Aug;21(2):189-201
• All: 29 reference(s)