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Ppiatm1Lubn
Targeted Allele Detail
Nomenclature
Symbol: Ppiatm1Lubn
Name: peptidylprolyl isomerase A; targeted mutation 1, Jeremy Luban
MGI ID: MGI:3505553
Synonyms: CypA-, Ppia-
Gene: Ppia  Location: Chr11:6365867-6369817 bp, + strand  Genetic Position: Chr11, 3.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93591
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced all but the last 60 bp of the coding sequence. Immunoblot analysis confirmed absence of protein in thymus, spleen, kidney, and brain. (J:64523)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ppia Mutation:  15 strains or lines available
References
Original:  J:93591 Colgan J, et al., Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk. Immunity. 2004 Aug;21(2):189-201
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory