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Targeted Allele Detail
Symbol: Dnmt1tm1(tetO-BCL2)Sjk
Name: DNA methyltransferase (cytosine-5) 1; targeted mutation 1, Stanley J Korsmeyer
MGI ID: MGI:3497721
Synonyms: Dnmt1tm1Sjk, tet-BCL-2
Gene: Dnmt1  Location: Chr9:20907206-20959888 bp, - strand  Genetic Position: Chr9, 7.66 cM
Germline Transmission:  Earliest citation of germline transmission: J:93549
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
Dnmt1tm1(tetO-BCL2)Sjk expresses 1 gene
Mutation detailsA targeting vector containing human BCL2 under the control of tet operator sequences and a minimal CMV promoter was inserted into the endogenous locus. (J:93549)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnmt1 Mutation:  44 strains or lines available
Original:  J:93549 Letai A, et al., Antiapoptotic BCL-2 is required for maintenance of a model leukemia. Cancer Cell. 2004 Sep;6(3):241-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory