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Pax7tm1(cre)Mrc
Targeted Allele Detail
Nomenclature
Symbol: Pax7tm1(cre)Mrc
Name: paired box 7; targeted mutation 1, Mario R Capecchi
MGI ID: MGI:3497712
Synonyms: Pax7-cre, Pax7ICNm
Gene: Pax7  Location: Chr4:139464373-139560839 bp, - strand  Genetic Position: Chr4, 70.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93443
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsAn IRES-Cre-FRT-neo-FRT cassette was inserted into the 3' UTR following the stop codon in exon 10. Crossing with mice expressing FLP-e excised the neo. The insertion did not interfere with normal Pax7 function. (J:93443)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pax7     Summary of all recombinase alleles driven by Pax7. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Pax7 Mutation:  35 strains or lines available
References
Original:  J:93443 Keller C, et al., Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin. Genes Dev. 2004 Dec 1;18(21):2608-13
All:  56 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory