Tg(Cryaa-Six3)53Pgr
Transgene Detail

Summary

• Symbol: Tg(Cryaa-Six3)53Pgr
• Name: transgene insertion 53, Peter Gruss
• MGI ID: MGI:3057335
• Synonyms: alphaASix3, Tg(aAcryst-Six3)F53
• Transgene: Tg(Cryaa-Six3)53Pgr Location: unknown
• Alliance: Tg(Cryaa-Six3)53Pgr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cryaa-Six3)53Pgr expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Six3 (MGI:102764)

• Mutation details: The transgene comprises a 0.4-kb DNA fragment containing the mouse crystallin, alpha 1 promoter driving expression of the mouse sine oculis-related homeobox 3 homolog (Drosophila) (Six3) protein from a full-length, 1.4-kb cDNA, which is followed by the SV40 intron and polyadenylation signal. Transgenic mRNA is detected from embryonic day 12 (E12.0); its expression was confined to lens fiber cells during the developmental period studied (E12.0 - E13.5) and spatially overlapped that of endogenous Pax6. (J:77351)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:77351 Goudreau G, et al., Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8719-24
• All: 1 reference(s)