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Targeted Allele Detail
Symbol: Rettm2(RET)Jmi
Name: ret proto-oncogene; targeted mutation 2, Jeffrey Milbrandt
MGI ID: MGI:3057332
Synonyms: Ret9, RetRET9
Gene: Ret  Location: Chr6:118151745-118197718 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Germline Transmission:  Earliest citation of germline transmission: J:93262
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Rettm2(RET)Jmi expresses 1 gene
Mutation detailsHuman RET9 cDNA and a floxed neo were inserted into exon 1 of the endogenous locus. Mating with mice expressing Cre in the germline excised the neo. RT-PCR showed expression of the mutant allele in brain. (J:93262)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ret Mutation:  36 strains or lines available
Original:  J:93262 Jain S, et al., Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis. Development. 2004 Dec;131(21):5503-13
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory