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Tg(CSF2)2Ygy
Transgene Detail
Nomenclature
Symbol: Tg(CSF2)2Ygy
Name: transgene insertion 2, Yong-guang Yang
MGI ID: MGI:3057263
Transgene: Tg(CSF2)2Ygy  Location: unknown  
Transgene
origin
Strain of Origin:  NIH Swiss
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CSF2)2Ygy expresses 1 gene
 
Mutation detailsThe transgene construct contains the porcine colony stimulating factor 2 (granulocyte-macrophage) sequence (CSF2) controlled by the human cytomegalovirus promoter. The Tg(IL3)1Ygy, Tg(CSF2)2Ygy and Tg(KITLG)3Ygy transgenic constructs were co-injected into NIH/Swiss oocytes in David Bodine's lab at NCI. (J:94302)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
White blood cells from mice that carry this transgene in conjunction with Tg(IL3)1Ygy and Tg(KITLG)3Ygy and that are also homozygous for Prkdcscid are CD4-, CD8-, CD3-, IgM-, CD19- and Mac-1+ by flow cytometric (FMC) analysis.
References
Original:  J:94302 Yang YG, et al., Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier. Xenotransplantation. 2000 Feb;7(1):58-64
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory