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Targeted Allele Detail
Symbol: Hsf4tm1Anak
Name: heat shock transcription factor 4; targeted mutation 1, Akira Nakai
MGI ID: MGI:3057199
Synonyms: Hsf4-
Gene: Hsf4  Location: Chr8:105996433-106002477 bp, + strand  Genetic Position: Chr8, 53.04 cM, cytoband D1
Germline Transmission:  Earliest citation of germline transmission: J:93301
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 2 and exons 3-8 were replaced with a neo. The deleted sequence encode amino acids 68-248 and include part of the DNA-binding domain and an oligomerization domain. Western blot and In situ hybridization of lenses from mutant mice confirmed lack of expression. (J:93301)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 120 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hsf4 Mutation:  24 strains or lines available
Original:  J:93301 Fujimoto M, et al., HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 2004 Nov 27;23(21):4297-306
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory