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Transgenic Allele Detail
Symbol: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan
Name: RIKEN cDNA 1700016L21 gene; transgene insertion 57, Richard A Lang
MGI ID: MGI:3057163
Synonyms: CD11cDTR, CD11c-DTR, CD11c.DTR, CD11c-DTR-GFP, CD11c-DTR/GFP, CD11cDTR tg, CD11c/DTR Tg, DCKO, DTR-GFP, DTR-GRP, Itgax-DTR, Tg.Itgax-DTR/EGFP.57Lan, Tg(Itgax-DTR/GFP)57Lan
Gene: 1700016L21Rik  Location: Chr1:80445932-80475660 bp, + strand  Genetic Position: Chr1, Syntenic
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe transgene contains a fusion product involving simian diphtheria toxin receptor and green fluorescent protein under the control of the mouse Itgax promoter (CD11c). Two lines were created (line 11 and line 57) with 1 to 2 copies and 20 copies of the transgene, respectively. All CD8+ and CD8- dendritic cells in the spleen fluoresce and are DT sensitive. Immunohistochemical and flow cytometric analyses show that expression of the transgene is specific to splenic dendritic cells. Line 57 inserted into the gene at 80448681-80455738 (Build GRCm38/mm10) resulting in a 7057 bp deletion. Founder line 57 has a copy number of greater than 20. (J:93488, J:253473)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any 1700016L21Rik Mutation:  4 strains or lines available
Original:  J:93488 Jung S, et al., In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity. 2002 Aug;17(2):211-20
All:  300 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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