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Transgenic Allele Detail
Symbol: Zbtb20Tg(PDGFB-APPSwInd)20Lms
Name: zinc finger and BTB domain containing 20; transgene insertion 20, Lennart Mucke
MGI ID: MGI:3057148
Synonyms: APP/J20, APP Tg, hAPPJ20, hAPP-J20, J20, PDAPP-J20, PDGF-APPSwInd, PDGF-hAPP695,751,770V171F, KM670/671NL, Tg(PDGFB-APP*Swe*Ind)20Lms
Gene: Zbtb20  Location: Chr16:42875689-43634392 bp, + strand  Genetic Position: Chr16, 28.44 cM, cytoband B4
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
Zbtb20Tg(PDGFB-APPSwInd)20Lms expresses 1 gene
Mutation detailsThe transgene expresses the mutant human amyloid protein precursor APPSwInd, which bears both the Swedish (K670N/M671L) and the Indiana (V717F) mutations, under the control of the human platelet derived growth factor, B polypeptide (PDGFB) promoter. Hemizygous transgenic mice express immunodetectable transgene product in cerebral neurons, with the highest level of expression occurring in the neocortex and hippocampus. ELISA analysis reveals approximate total amyloid beta peptides and 42 amino acid length amyloid beta peptides in neocortical and hippocampal tissue from transgenic mice. Line 20 inserted into an intron of the gene at 43086322-43127049 (Build GRCm38/mm10) resulting in a 40,727 bp deletion. Founder line 20 has a copy number of greater than 10. (J:62290, J:253473)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 3 lines available
Carrying any Zbtb20 Mutation:  28 strains or lines available
This line is also called line J20.

Diffuse amyloid beta peptides deposition forms in the dendate gyrus and neocortex at 5 to 7 months of age. Amyloid deposition is progressive, with all transgenic mice exhibiting plaques by age 8 to 10 months.

Original:  J:62290 Mucke L, et al., High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci. 2000 Jun 1;20(11):4050-8
All:  186 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory