About   Help   FAQ
Tg(PDGFB-APPSwInd)20Lms
Transgene Detail
Nomenclature
Symbol: Tg(PDGFB-APPSwInd)20Lms
Name: transgene insertion 20, Lennart Mucke
MGI ID: MGI:3057148
Synonyms: APP/J20, APP Tg, hAPPJ20, J20, PDAPP-J20, PDGF-APPSwInd, PDGF-hAPP695,751,770V171F, KM670/671NL
Transgene: Tg(PDGFB-APPSwInd)20Lms  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
This line is also called line J20.

Diffuse amyloid beta peptides deposition forms in the dendate gyrus and neocortex at 5 to 7 months of age. Amyloid deposition is progressive, with all transgenic mice exhibiting plaques by age 8 to 10 months.

References
Original:  J:62290 Mucke L, et al., High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci. 2000 Jun 1;20(11):4050-8
All:  101 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory