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Transgene Detail
Symbol: Tg(MAPT)8cPdav
Name: transgene insertion 8c, Peter Davies
MGI ID: MGI:3057129
Synonyms: 8c, hTau
Transgene: Tg(MAPT)8cPdav  Location: unknown  
Beta-amyloid plaques in Tg(APPswe,PSEN1dE9)85Dbo/0 mice and neurofibrillary tangles in Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/0 mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  Swiss Webster x (C57BL/6 x DBA)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intergenic deletion
Tg(MAPT)8cPdav expresses 1 gene
Mutation detailsThe transgene contains the coding sequence, intronic regions, and regulatory elements of the human microtubule-associated protein tau (MAPT) gene. (J:85952)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Mice that are homozygous for the Mapttm1(GFP)Klt allele and hemizygous for the transgene are viable and fertile. Although no endogenous mouse MAPT is detected, all six isoforms (including both 3R and 4R forms) of human MAPT are expressed. Hyperphosphorylated MAPT is detected in cell bodies and dendrites by 3 months of age. Paired helical filaments of aggregated insoluble MAPT can be isolated from brain tissue as early as 2 months of age.
Original:  J:85952 Duff K, et al., Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes. Neurobiol Dis. 2000 Apr;7(2):87-98
All:  72 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory