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Tg(Cd8aCd8b)3Erob
Transgene Detail
Nomenclature
Symbol: Tg(Cd8aCd8b)3Erob
Name: transgene insertion 3, Ellen Robey
MGI ID: MGI:3056809
Transgene: Tg(Cd8aCd8b)3Erob  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Cd8aCd8b)3Erob expresses 1 gene
 
Mutation detailsThe murine Cd8a and Cd8b1 coding sequences were placed under the control of the T cell-specific CD2 promoter. Six copies of the transgene incorporated into the genome. The resulting heterodimer complex expressed was the "CD8.1" variant that differs from the "CD8.2" variant complex normally expressed in C57BL/6 mice. Transgenic expression was detected on almost all thymocytes and T cells as determined by flow cytometry using antibodies that can distinguish the two CD8 variants. (J:93004)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:93004 Robey EA, et al., Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell. 1991 Jan 11;64(1):99-107
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory