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Transgene Detail
Symbol: Tg(HBA-HBBs)41Paz
Name: transgene insertion 41, Chris Paszty
MGI ID: MGI:3056733
Synonyms: miniLCRalpha1GgammaAgammadeltabetaS, Tg(Hu-miniLCRalpha1GgammaAgammadeltabetaS)
Transgene: Tg(HBA-HBBs)41Paz  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(HBA-HBBs)41Paz expresses 6 genes
Mutation detailsThe transgene contains sequences encoding the human proteins HBA1 (hemoglobin, alpha 1), HBG2 (hemoglobin, gamma G, fetal component), HBG1 (hemoglobin, gamma A, fetal component), HBD (hemoglobin, delta), and HBB S (hemoglobin, beta, sickle allele), and the locus control region (LCR). The HBBS allele contains an A to T transversion mutation in the sixth codon of HBB which causes an amino acid change from Glu to Val. The transgene promoter is multiple: from alpha and beta globin human loci. Transgenic mice express human alpha hemoglobin, gamma hemoglobin, and sickle cell hemoglobin. (J:44161)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
In conjunction with Hbatm1Paz and Hbbtm1Tmt, transgenic mice express exclusively human sickle hemoglobin. These mice do not express mouse Hba and Hbb, but do express human HBA and HBB. Although chronically anemic, most of these mice survive for 2 to 9 months and are fertile. A significant percentage of sickle cell mice do not survive to adulthood. These mice display the major genetic, hematologic and histopathologic features found in humans with sickle cell disease: irreversibly sickled red cells, anemia, and multiorgan pathology.

Original:  J:44161 Paszty C, et al., Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease [see comments]. Science. 1997 Oct 31;278(5339):876-8
All:  49 reference(s)

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