About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Tg(FCGR2A)11Mkz
Transgene Detail
Nomenclature
Symbol: Tg(FCGR2A)11Mkz
Name: transgene insertion 11, Steven E McKenzie
MGI ID: MGI:3056729
Synonyms: huFCGR2AR131
Transgene: Tg(FCGR2A)11Mkz  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(FCGR2A)11Mkz expresses 1 gene
 
Mutation detailsThe transgene contains the human FCGR2A gene. The genomic clone used in the transgene encodes the R131 polymorphic form of human FcgRIIA, which binds the widest range of mouse IgG subclasses including mouse IgG1 and rat IgG2a as well. 10 copies of the transgene was estimated to have inserted into the genome. Transgenic mice express human FCGR2A on mouse platelets and macrophages at levels equivalent to that observed in human cells. (J:93244, J:136516)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Phenotypic Similarity to Human Syndrome: heparin-induced thrombocytopenia (HIT) / Thrombocytopenia and Thrombosis (HITT) (J:72220)

References
Original:  J:93244 McKenzie SE, et al., The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model. J Immunol. 1999 May 1;162(7):4311-8
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/20/2015
MGI 5.21
The Jackson Laboratory