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Thtm1(cre)Te
Targeted Allele Detail
Nomenclature
Symbol: Thtm1(cre)Te
Name: tyrosine hydroxylase; targeted mutation 1, Ted Ebendal
MGI ID: MGI:3056580
Synonyms: TEb-3, Thcre, ThIRES-Cre, Th-IRES-Cre, Th::IRES-Cre
Gene: Th  Location: Chr7:142892779-142899995 bp, - strand  Genetic Position: Chr7, 88.06 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93194
Parent Cell Line:  GSI-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsAn IRES-cre cassette and FRT-flanked neo was inserted into the 3' UTR. Crossing with FLP deleter mice excised the neo. Immunostaining demonstrated that the inserted sequence did not interfere with endogenous expression and that cre was expressed in mutant mesencephalon and adrenal gland. Cre expression is also detected in oocytes. (J:93194)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Th     Summary of all recombinase alleles driven by Th. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 14 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Th Mutation:  45 strains or lines available
References
Original:  J:93194 Lindeberg J, et al., Transgenic expression of Cre recombinase from the tyrosine hydroxylase locus. Genesis. 2004 Oct;40(2):67
All:  57 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory