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Targeted Allele Detail
Symbol: Alcamtm1Jawe
Name: activated leukocyte cell adhesion molecule; targeted mutation 1, Joshua A Weiner
MGI ID: MGI:3056579
Synonyms: BEN-
Gene: Alcam  Location: Chr16:52248996-52453081 bp, - strand  Genetic Position: Chr16, 32.88 cM, cytoband B5
Germline Transmission:  Earliest citation of germline transmission: J:93205
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 was replaced by EGFP and loxP flanked neo via homologous recombination. Neo was removed via cre mediated recombination of the flanking loxP sites, resulting in increased GFP expression. Northern and immunohistochemical analysis confirmed the absence of RNA in adult brain and protein in E12 spinal cords. (J:93205)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Alcam Mutation:  3 strains or lines available
Original:  J:93205 Weiner JA, et al., Axon fasciculation defects and retinal dysplasias in mice lacking the immunoglobulin superfamily adhesion molecule BEN/ALCAM/SC1. Mol Cell Neurosci. 2004 Sep;27(1):59-69
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory