About   Help   FAQ
Alcamtm1Jawe
Targeted Allele Detail
Nomenclature
Symbol: Alcamtm1Jawe
Name: activated leukocyte cell adhesion molecule; targeted mutation 1, Joshua A Weiner
MGI ID: MGI:3056579
Synonyms: BEN-
Gene: Alcam  Location: Chr16:52248996-52453081 bp, - strand  Genetic Position: Chr16, 32.88 cM, cytoband B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93205
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced by EGFP and loxP flanked neo via homologous recombination. Neo was removed via cre mediated recombination of the flanking loxP sites, resulting in increased GFP expression. Northern and immunohistochemical analysis confirmed the absence of RNA in adult brain and protein in E12 spinal cords. (J:93205)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Alcam Mutation:  3 strains or lines available
References
Original:  J:93205 Weiner JA, et al., Axon fasciculation defects and retinal dysplasias in mice lacking the immunoglobulin superfamily adhesion molecule BEN/ALCAM/SC1. Mol Cell Neurosci. 2004 Sep;27(1):59-69
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/18/2020
MGI 6.14
The Jackson Laboratory