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Targeted Allele Detail
Symbol: Dll4tm1Jrt
Name: delta like canonical Notch ligand 4; targeted mutation 1, Janet Rossant
MGI ID: MGI:3056400
Synonyms: Dll4LacZ
Gene: Dll4  Location: Chr2:119325784-119335666 bp, + strand  Genetic Position: Chr2, 59.97 cM, cytoband E3
Germline Transmission:  Earliest citation of germline transmission: J:93157
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 2 kb segment including the start codon a first 3 exons was replaced with a lacZ and PGK-neo cassette via homologous recombination. RT-PCR confirmed the lack of expression in homozygotes. LacZ expression is similar to endogenous expression. (J:93157)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 123 assay results
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dll4 Mutation:  17 strains or lines available
Original:  J:93157 Duarte A, et al., Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev. 2004 Oct 15;18(20):2474-8
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory