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Hoxa1tm1Rez
Targeted Allele Detail
Summary
Symbol: Hoxa1tm1Rez
Name: homeobox A1; targeted mutation1 1, Rene Rezsohazy
MGI ID: MGI:3056069
Synonyms: Hoxa1WM-AA
Gene: Hoxa1  Location: Chr6:52132573-52135299 bp, - strand  Genetic Position: Chr6, 25.4 cM
Alliance: Hoxa1tm1Rez page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93020
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Nucleotide substitutions
 
Mutation detailsA targeting vector was designed replace the WM residues with AA residues in the hexapeptide sequence of the endogenous locus. Crossing with ubiquitously expressing Cre mice excised a floxed neo that was also introduced by the vector. Neither the expression level nor the stability of the protein was altered. (J:93020)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa1 Mutation:  14 strains or lines available
References
Original:  J:93020 Remacle S, et al., Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo. Mol Cell Biol. 2004 Oct;24(19):8567-75
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory