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Sil1wz
Spontaneous Allele Detail
Nomenclature
Symbol: Sil1wz
Name: endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae); woozy
MGI ID: MGI:3055918
Gene: Sil1  Location: Chr18:35399449-35632443 bp, - strand  Genetic Position: Chr18, 18.97 cM
Mutation
origin
Strain of Origin:  CXB5/ByJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Transposon insertion
 
Mutation detailsMutant transcripts demonstrate splicing between exon 7 of Sil1 and an ETn retrotransposon inserted between position 4,799 and 4,800. The chimeric transcript has an in-frame stop codon after 96 nucleotides of ETn sequence. (J:100860)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sil1 Mutation:  23 strains or lines available
References
Original:  J:100860 Zhao L, et al., Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP. Nat Genet. 2005 Sep;37(9):974-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory