Cd244a^tm1Kmle
Targeted Allele Detail

Summary

• Symbol: Cd244a^tm1Kmle
• Name: CD244 molecule A; targeted mutation 1, Kyung-Mi Lee
• MGI ID: MGI:3055564
• Synonyms: 2B4^-
• Gene: Cd244a Location: Chr1:171386287-171412884 bp, + strand Genetic Position: Chr1, 79.52 cM
• Alliance: Cd244a^tm1Kmle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93012
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was used to replace the extracellular region, exon 2 and part of exon 3 with a PGK-neo. Flow cytometry indicated that mutant mice did not express the protein. (J:94750)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd244a Mutation: 24 strains or lines available

References

• Original: J:93012 Lee KM, et al., 2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells. J Exp Med. 2004 May 3;199(9):1245-54
• All: 25 reference(s)