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Nrg2tm1Bus
Targeted Allele Detail
Nomenclature
Symbol: Nrg2tm1Bus
Name: neuregulin 2; targeted mutation 1, Samantha J Busfield
MGI ID: MGI:3055488
Synonyms: NRG-2
Gene: Nrg2  Location: Chr18:36017707-36197380 bp, - strand  Genetic Position: Chr18, 19.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92972
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exons 2-4 of the gene. The deleted region encodes the immunoglobulin domain and most of the epidermal growth factor-like domain. RT-PCR analysis on adult cerebellum and cortex/hippocampus showed no detectable transcript. (J:92972)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg2 Mutation:  16 strains or lines available
Notes
ES cell line derived from 129X1/SvJ.
References
Original:  J:92972 Britto JM, et al., Generation and characterization of neuregulin-2-deficient mice. Mol Cell Biol. 2004 Sep;24(18):8221-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory