About   Help   FAQ
Targeted Allele Detail
Symbol: Sh2b1tm1Lr
Name: SH2B adaptor protein 1; targeted mutation 1, Liangyou Rui
MGI ID: MGI:3055487
Synonyms: SH2-B-
Gene: Sh2b1  Location: Chr7:126066166-126074596 bp, - strand  Genetic Position: Chr7, 69.06 cM
Germline Transmission:  Earliest citation of germline transmission: J:92794
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe promoter region through the majority of the coding sequence was replaced with a neomycin resistance gene. All isoforms are predicted to be eliminated and immunoblot confirmed that no wild-type protein was present in mutant livers. (J:92794)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sh2b1 Mutation:  15 strains or lines available
Original:  J:92794 Duan C, et al., Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Mol Cell Biol. 2004 Sep;24(17):7435-43
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.17
The Jackson Laboratory