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Tg(CD8aCD8b)57Scr
Transgene Detail
Nomenclature
Symbol: Tg(CD8aCD8b)57Scr
Name: transgene insertion 57, The Scripps Research Institute
MGI ID: MGI:3055355
Transgene: Tg(CD8aCD8b)57Scr  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CD8aCD8b)57Scr expresses 2 genes
 
Mutation detailsThe transgene contains the human CD8 alpha and beta chain genes driven by the T cell-specific Lck promoter. CD8alpha-alpha homodimers were expressed on 62% of thymocytes and CD8alpha-beta heterodimers on 14% of thymocytes. Peripheral T cells preferentially expressed the CD8alpha-beta heterodimers at a 4:1 ratio. Human CD8alpha was detected on both CD4+ and CD8+ T cells. (J:92994)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:92994 LaFace DM, et al., Human CD8 transgene regulation of HLA recognition by murine T cells. J Exp Med. 1995 Nov 1;182(5):1315-25
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory