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Tg(TCRA)B1Jg
Transgene Detail
Nomenclature
Symbol: Tg(TCRA)B1Jg
Name: transgene insertion B1, Joan M Goverman
MGI ID: MGI:3055333
Transgene: Tg(TCRA)B1Jg  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x DBA/2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TCRA)B1Jg expresses 1 gene
 
Mutation detailsA functionally rearranged Tcra gene was used in the construction of this transgene. A recombined Tcra gene with Valpha2.3 and JalphaTA39 gene segments was cloned from the B10.PL hybridoma "172.10". This hybridoma was specific for the 11 amino-terminal residues of myelin basic protein (MBP). Crossing this line with the Tg(TCRB)C14Jg line produces a T cell with a transgenic TCR that has high affinity for the first 11 amino acids of MBP. In these doubly transgenic mice, 50-95% of CD3+ cells expressed the transgenic Tcra gene. (J:92991)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:92991 Goverman J, et al., Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell. 1993 Feb 26;72(4):551-60
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory