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Targeted Allele Detail
Symbol: Rettm1Mat
Name: ret proto-oncogene; targeted mutation 1, Masahide Takahashi
MGI ID: MGI:3055332
Synonyms: c-Ret-KIY1062F, Y1062F
Gene: Ret  Location: Chr6:118151745-118197718 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Germline Transmission:  Earliest citation of germline transmission: J:92802
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
Mutation detailsThe introduction of a targeting vector resulted in two amino acid replacements, KLY1062 to KIF1062, within exon 19 and a floxed PGK-neo inserted into intron 19. RT-PCR indicated that the substitutions did not inhibit correct splicing in mutants, nor did the neo create significant differences in protein expression between mutant and wild-type mice. (J:92802)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ret Mutation:  35 strains or lines available
Original:  J:92802 Jijiwa M, et al., A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia. Mol Cell Biol. 2004 Sep;24(18):8026-36
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory