Stat5a^tm2Mam
Targeted Allele Detail

Summary

• Symbol: Stat5a^tm2Mam
• Name: signal transducer and activator of transcription 5A; targeted mutation 2, Lothar Hennighausen
• MGI ID: MGI:3055318
• Synonyms: Stat5a/Stat5b^tm2Mam, Stat5^fl
• Gene: Stat5a Location: Chr11:100750177-100775995 bp, + strand Genetic Position: Chr11, 63.77 cM
• Alliance: Stat5a^tm2Mam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92770
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Targeting vectors were designed to insert a floxed hygro downstream of the gene. This allele was generated in conjunction with Stat5b^tm1Mam. (J:92770)

Expression

In Mice Carrying this Mutation:	208072 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stat5a Mutation: 48 strains or lines available

References

• Original: J:92770 Cui Y, et al., Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol. 2004 Sep;24(18):8037-47
• All: 98 reference(s)