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Targeted Allele Detail
Symbol: Psmb8tm1Hjf
Name: proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); targeted mutation 1, H J Fehling
MGI ID: MGI:3055222
Synonyms: beta5i-, LMP-7-, LMP7-
Gene: Psmb8  Location: Chr17:34417169-34420428 bp, + strand  Genetic Position: Chr17, 17.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:20012
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1-5, encoding the first 247 amino acids of the protein, were replaced with a neomycin resistance gene. (J:20012)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Psmb8 Mutation:  12 strains or lines available
Original:  J:20012 Fehling HJ, et al., MHC class I expression in mice lacking the proteasome subunit LMP-7. Science. 1994 Aug 26;265(5176):1234-7
All:  64 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory