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Rasgrp2tm1Amg
Targeted Allele Detail
Nomenclature
Symbol: Rasgrp2tm1Amg
Name: RAS, guanyl releasing protein 2; targeted mutation 1, Ann M Graybiel
MGI ID: MGI:3055135
Synonyms: CalDAG-GEFI-
Gene: Rasgrp2  Location: Chr19:6449370-6465246 bp, + strand  Genetic Position: Chr19, 4.58 cM, cytoband A
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92864
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA frameshift mutation that results in a premature stop codon at amino acid 37 was introduced via homologous recombination. Immunohistochemistry and western blot analysis confirm the absence of protein in homozygous mutants. (J:92864)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rasgrp2 Mutation:  36 strains or lines available
References
Original:  J:92864 Crittenden JR, et al., CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med. 2004 Sep;10(9):982-986
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/14/2022
MGI 6.19
The Jackson Laboratory