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Targeted Allele Detail
Symbol: Map3k8tm1Tmat
Name: mitogen-activated protein kinase kinase kinase 8; targeted mutation 1, Tetsuya Matsuguchi
MGI ID: MGI:3055130
Synonyms: Cot/Tpl2-
Gene: Map3k8  Location: Chr18:4331325-4352953 bp, - strand  Genetic Position: Chr18, 2.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:187216
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene replaced the 3' half of exon 2 and the 5' half of exon 3, encoding the ATP-binding domain (residues 123-224). Western blot analysis showed no protein in mutants. (J:92844, J:187216)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map3k8 Mutation:  21 strains or lines available
Original:  J:187216 Kikuchi T, et al., Cot/Tpl2 is essential for RANKL induction by lipid A in osteoblasts. J Dent Res. 2003 Jul;82(7):546-50
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory