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Casp8tm1Wll
Targeted Allele Detail
Nomenclature
Symbol: Casp8tm1Wll
Name: caspase 8; targeted mutation 1, David Wallach
MGI ID: MGI:3054930
Synonyms: Casp8F
Gene: Casp8  Location: Chr1:58795374-58847503 bp, + strand  Genetic Position: Chr1, 29.19 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92722
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting construct was created to place a loxP site upstream of exon 1 and a floxed neo downstream of exon 2. Transient Cre expression excised the floxed neo. (J:92722)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp8 Mutation:  32 strains or lines available
References
Original:  J:92722 Kang TB, et al., Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol. 2004 Sep 1;173(5):2976-84
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory