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Targeted Allele Detail
Symbol: Tnfrsf13ctm1Mass
Name: tumor necrosis factor receptor superfamily, member 13c; targeted mutation 1, Marc Schmidt-Supprian
MGI ID: MGI:3054891
Synonyms: Baff-r-, BAFFR-
Gene: Tnfrsf13c  Location: Chr15:82221743-82224369 bp, - strand  Genetic Position: Chr15, 38.56 cM
Germline Transmission:  Earliest citation of germline transmission: J:92732
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsCre-recombinase excised a floxed region containing exons 3 and 4. The excised region encoded the entire extracellular and transmembrane domains and part of the cytoplasmic domain. RT-PCR did not detect mRNA in mutants. FACS analysis showed no surface expression of mutant splenic cells. (J:92732)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf13c Mutation:  7 strains or lines available
Original:  J:92732 Sasaki Y, et al., TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology. J Immunol. 2004 Aug 15;173(4):2245-52
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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