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Tnfrsf13ctm1Mass
Targeted Allele Detail
Nomenclature
Symbol: Tnfrsf13ctm1Mass
Name: tumor necrosis factor receptor superfamily, member 13c; targeted mutation 1, Marc Schmidt-Supprian
MGI ID: MGI:3054891
Synonyms: Baff-r-, BAFFR-
Gene: Tnfrsf13c  Location: Chr15:82221744-82224339 bp, - strand  Genetic Position: Chr15, 38.56 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92732
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCre-recombinase excised a floxed region containing exons 3 and 4. The excised region encoded the entire extracellular and transmembrane domains and part of the cytoplasmic domain. RT-PCR did not detect mRNA in mutants. FACS analysis showed no surface expression of mutant splenic cells. (J:92732)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf13c Mutation:  5 strains or lines available
References
Original:  J:92732 Sasaki Y, et al., TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology. J Immunol. 2004 Aug 15;173(4):2245-52
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory