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Cd22tm3Tft
Targeted Allele Detail
Nomenclature
Symbol: Cd22tm3Tft
Name: CD22 antigen; targeted mutation 3, Thomas F Tedder
MGI ID: MGI:3054888
Synonyms: Cd22delta1-2
Gene: Cd22  Location: Chr7:30865404-30880342 bp, - strand  Genetic Position: Chr7, 19.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92736
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 3 and 4 were deleted following Cre-mediated excision of a floxed neo. A 3' mRNA splice junction of exon 3 was retained. Immunoblot and flow cytometry confirmed protein expression by B cells. Protein migrated as a 120 kDa fragment, the predicted size of the protein lacking two immunoglobulin-like domains. (J:92736)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd22 Mutation:  38 strains or lines available
References
Original:  J:92736 Poe JC, et al., CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms. Nat Immunol. 2004 Oct;5(10):1078-87
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory