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Targeted Allele Detail
Symbol: Prkacatm2Gsm
Name: protein kinase, cAMP dependent, catalytic, alpha; targeted mutation 2, G Stanley McKnight
MGI ID: MGI:3054825
Gene: Prkaca  Location: Chr8:83972993-83996443 bp, + strand  Genetic Position: Chr8, 40.22 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:92616
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
Mutation detailsThis allele carries a loxP site and a mutation of the translation initiation codon in every reading frame in exon 1b. Western blot confirmed absence of protein in testes and sperm. (J:92616)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkaca Mutation:  14 strains or lines available
Original:  J:92616 Nolan MA, et al., Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13483-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory