Foxn4^tm1Xia
Targeted Allele Detail

Summary

• Symbol: Foxn4^tm1Xia
• Name: forkhead box N4; targeted mutation 1, Mengqing Xiang
• MGI ID: MGI:3054789
• Synonyms: Foxn4^-, Foxn4^KO, Foxn4^lacZ
• Gene: Foxn4 Location: Chr5:114392225-114411868 bp, - strand Genetic Position: Chr5, 55.99 cM
• Alliance: Foxn4^tm1Xia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92622
• Parent Cell Line: CMT-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ and PGK-neo cassette replaced seven of the nine coding exons, including those coding for the forkhead/winged helix DNA binding domain. Gene disruption was confirmed by lack of signal for the protein in in situ hybridization of embryonic retinas. (J:92622)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxn4 Mutation: 31 strains or lines available

References

• Original: J:92622 Li S, et al., Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors. Neuron. 2004 Sep 16;43(6):795-807
• All: 13 reference(s)