Tg(APOE-CYP4B1)1Yfsi
Transgene Detail

Summary

• Symbol: Tg(APOE-CYP4B1)1Yfsi
• Name: transgene insertion 1, Yoshihiko Funae and Susumu Imaoka
• MGI ID: MGI:3054634
• Transgene: Tg(APOE-CYP4B1)1Yfsi Location: unknown
• Alliance: Tg(APOE-CYP4B1)1Yfsi page

Transgene origin

• Strain of Origin: (C57BL/6CrSlc x DBA/2CrSlc)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOE-CYP4B1)1Yfsi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CYP4B1 (1580)

  Cyp4b1

  (MGI:103225)

• Mutation details: The transgene comprises the entire coding sequence of human cytochrome P450, family 4, subfamily b, polypeptide 1 (CYP4B1) cDNA coupled to the 5' flanking region and hepatic control sequence of the human apolipoprotein E gene. Immunoblot analysis of hepatic microsomes from transgenic mice revealed an immunoreactive protein having the mobility of human CYP4B1. Lauric acid omega-hydroxylation was 25% greater and mutagenic activation of 2-aminofluorene two-fold greater in transgenic than in control liver microsomes; both these activities were abrogated by antibodies to CYP4B1. (J:70026)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:70026 Imaoka S, et al., A transgenic mouse expressing human CYP4B1 in the liver. Biochem Biophys Res Commun. 2001 Jun 15;284(3):757-62
• All: 1 reference(s)