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Dmpktm1Bew
Targeted Allele Detail
Nomenclature
Symbol: Dmpktm1Bew
Name: dystrophia myotonica-protein kinase; targeted mutation 1, Be Wieringa
MGI ID: MGI:3054407
Synonyms: Dmpk-
Gene: Dmpk  Location: Chr7:19083849-19093821 bp, + strand  Genetic Position: Chr7, 9.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33711
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 4.5 kb segment, including the ATG start site ant 10 of the 11 conserved kinase domains, was replaced with a hygroB cassette via homologous recombination. Northern and western blot analysis confirmed the absence of mRNA and protein. Recombination also disrupted the polyadenylation signal of the upstream gene, Dmwd, resulting in production of a larger transcript but no significant change in expression level. (J:33711)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dmpk Mutation:  10 strains or lines available
References
Original:  J:33711 Jansen G, et al., Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice [see comments]. Nat Genet. 1996 Jul;13(3):316-24
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory