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Tg(PF4MER)6Kra
Transgene Detail
Nomenclature
Symbol: Tg(PF4MER)6Kra
Name: transgene insertion 6, Katya Ravid
MGI ID: MGI:3054406
Synonyms: PF4MERGH
Transgene: Tg(PF4MER)6Kra  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(PF4MER)6Kra expresses 1 gene
 
Mutation detailsThe transgene is a 3.9-kb fragment which contains the rat platelet factor 4 (Pf4) promoter followed by exons 2 and 3 of human myc fused to the human estrogen receptor (MER), followed by a 442-base pair region of the HGH poly(A) tail starting from the stop codon of the HGH gene. Two copies of the transgene integrated in this line. Expression of the transgene was detected in bone marrow megakaryocytes. (J:35507)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Mice homozygous for this transgene on an FVB/N background are viable and fertile. Expression of the transgene is exclusively in platelets and megakaryocytes in female carrier mice or in male carrier mice given injections of estrogen. Megakaryopoiesis is increased and they exhibit essential thrombocythemia. This strain may serve as a model for a myeloproliferative disorder resembling essential thrombocythemia.
References
Original:  J:35507 Thompson A, et al., Deregulated expression of c-myc in megakaryocytes of transgenic mice increases megakaryopoiesis and decreases polyploidization. J Biol Chem. 1996 Sep 20;271(38):22976-82
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory