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Tg(Mt1-RET)242Ina
Transgene Detail
Nomenclature
Symbol: Tg(Mt1-RET)242Ina
Name: transgene insertion 242, Izumi Nakashima
MGI ID: MGI:3053982
Synonyms: Tg(Mt1-RET)242Num, Tg(Mt1-RFP/FET)242Num
Transgene: Tg(Mt1-RET)242Ina  Location: unknown  
Transgene
origin
Strain of Origin:  (BALB/c x C57BL/6) X BALB/c
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgene comprises the cDNA encoding the human ret proto-oncogene driven by the mouse metallothionein 1 promoter/enhancer and followed by a segment of the simian virus 40 (SV40) genome containing a splice signal, a polyadenylation signal and 3' flanking sequence. Northern blot analysis revealed low levels of transgene expression in hyperpigmented skin of non-albino mice of this line. (J:70622)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Notes
Sublines 242A, 242B and 242C were derived by crossing early descendants of female founder 242, on a mixed BALB/c and C57BL/6 background, to C57BL/6, (BALB/c x C57BL/6)F1 or BALB/c mice, respectively, then intercrossing the progeny. Other founder lines were 108, 192, 207, 301, 304 and 319.
References
Original:  J:70622 Iwamoto T, et al., Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene. EMBO J. 1991 Nov;10(11):3167-75
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory