Shh^{tm2(cre/ERT2)Cjt}
Targeted Allele Detail

Summary

• Symbol: Shh^{tm2(cre/ERT2)Cjt}
• Name: sonic hedgehog; targeted mutation 2, Clifford J Tabin
• MGI ID: MGI:3053960
• Synonyms: Shh-cre, Shh^CreER, ShhCre^ER, Shh^creERT2, ShhcreER^T2, Shh^CreERT2, Shh^Creesr, Shh^{tm2(cre-ERT2)Cjt}, Shh^{tm2(cre/ESR1)Cjt}
• Gene: Shh Location: Chr5:28661838-28672099 bp, - strand Genetic Position: Chr5, 14.39 cM
• Alliance: Shh^{tm2(cre/ERT2)Cjt} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92504
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Shh^{tm2(cre/ERT2)Cjt} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Shh (MGI:98297)

• Mutation details: A cassette containing CreER^T2 was inserted at the ATG. Upon recombination, the first 35 base pairs after the ATG were deleted. Cre was produced in all cells in which the endogenous mRNA was normally expressed. (J:92504)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Shh (mouse) Summary of all recombinase alleles driven by Shh. Comparative matrix view of recombinase activities Alliance mouse Shh gene page

Expression

In Mice Carrying this Mutation:

5 assay results

Tumor Data

List all tumor models in MMHCdb carrying Shh^{tm2(cre/ERT2)Cjt}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Shh Mutation: 45 strains or lines available

References

• Original: J:92504 Harfe BD, et al., Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. 2004 Aug 20;118(4):517-28
• All: 116 reference(s)