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Shhtm1(EGFP/cre)Cjt
Targeted Allele Detail
Nomenclature
Symbol: Shhtm1(EGFP/cre)Cjt
Name: sonic hedgehog; targeted mutation 1, Clifford J Tabin
MGI ID: MGI:3053959
Synonyms: Shh-cre, ShhCreEGFP, Shhcre/Gfp, Shhgfpcre, Shhgfpcre, Shhgfp-Cre, ShhGFP-Cre, Shh-GFP-Cre
Gene: Shh  Location: Chr5:28456840-28467101 bp, - strand  Genetic Position: Chr5, 14.39 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92504
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA cassette containing an in frame fusion between GFP and cre was inserted at the ATG. Upon recombination, the first 35 base pairs after the ATG were deleted. Fluorescence was detected in the distal posterior region of E10-E12 embryos. (J:92504)
Recombinase
activity
Activity:
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Driver: Shh     Summary of all recombinase alleles driven by Shh. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 36 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Shh Mutation:  23 strains or lines available
References
Original:  J:92504 Harfe BD, et al., Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. 2004 Aug 20;118(4):517-28
All:  194 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory