Shh^{tm1(EGFP/cre)Cjt}
Targeted Allele Detail

Summary

• Symbol: Shh^{tm1(EGFP/cre)Cjt}
• Name: sonic hedgehog; targeted mutation 1, Clifford J Tabin
• MGI ID: MGI:3053959
• Synonyms: Shh-cre, Shh^CreEGFP, Shh^cre/Gfp, Shhgfpcre, Shh^gfpcre, Shhgfp-Cre, Shh^GFP-Cre, Shh-GFP-Cre
• Gene: Shh Location: Chr5:28661838-28672099 bp, - strand Genetic Position: Chr5, 14.39 cM
• Alliance: Shh^{tm1(EGFP/cre)Cjt} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92504
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Shh^{tm1(EGFP/cre)Cjt} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Shh (MGI:98297)

• Mutation details: A cassette containing an in frame fusion between GFP and cre was inserted at the ATG. Upon recombination, the first 35 base pairs after the ATG were deleted. Fluorescence was detected in the distal posterior region of E10-E12 embryos. (J:92504)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Shh (mouse) Summary of all recombinase alleles driven by Shh. Comparative matrix view of recombinase activities Alliance mouse Shh gene page

Expression

In Mice Carrying this Mutation:	712 assay results 37 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Shh Mutation: 45 strains or lines available

References

• Original: J:92504 Harfe BD, et al., Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. 2004 Aug 20;118(4):517-28
• All: 282 reference(s)